Difference between revisions of "Bovine Herpesvirus 1"
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====Pathogenesis==== | ====Pathogenesis==== | ||
| − | IBR: | + | '''IBR''': |
| + | *BHV-1 infects the respiratory mucosal epithelial cells (intranuclear inclusion eosinophilic inclusion bodies)from nasal mucosa down to bronchioles | ||
| + | **Leading to neutrophilic inflammation of varying severity: serous -> catarrhal -> purulent nasal discharge, sneezing, coughing | ||
*Dypsnoea, anorexia | *Dypsnoea, anorexia | ||
| − | * | + | *Rhinotracheitis that can develop into bronchopneumonia |
| − | * | + | *Clinical signs include coughing, discharge, lacrimation, and increased respiratory rate |
| − | IPV: | + | *Clinical disease most severe in young calves - can develop mucosal ulcerative lesions in the oesophagus and forestomachs and viraemia with multiorgan infection |
| + | *Generally high morbidity, low mortality, but up to 75% mortality if concurrent with [[Bovine Virus Diarrhoea Virus|BVDV]], caused by meningo-encephalitis | ||
| + | |||
| + | '''IPV''': | ||
*Painful genital lesions | *Painful genital lesions | ||
*Impaired reproductive performance | *Impaired reproductive performance | ||
Revision as of 17:49, 29 October 2008
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This article is still under construction. |
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Antigenicity
- Two different viruses:
- Infectious bovine rhinotracheitis (IBR): aerosol transfer
- Infectrious Pustular Vulvovaginitis (IPV): venereal transfer
Pathogenesis
IBR:
- BHV-1 infects the respiratory mucosal epithelial cells (intranuclear inclusion eosinophilic inclusion bodies)from nasal mucosa down to bronchioles
- Leading to neutrophilic inflammation of varying severity: serous -> catarrhal -> purulent nasal discharge, sneezing, coughing
- Dypsnoea, anorexia
- Rhinotracheitis that can develop into bronchopneumonia
- Clinical signs include coughing, discharge, lacrimation, and increased respiratory rate
- Clinical disease most severe in young calves - can develop mucosal ulcerative lesions in the oesophagus and forestomachs and viraemia with multiorgan infection
- Generally high morbidity, low mortality, but up to 75% mortality if concurrent with BVDV, caused by meningo-encephalitis
IPV:
- Painful genital lesions
- Impaired reproductive performance
- Frequent micturition
Diagnosis
- Virus isolation and immunofluorescence
Control
- Vaccination:
- Two live attenuated vaccines are available in the UK, one is temperature-sensitive
- Both given intranasally
- Neither protect against re-infection when given during clinical outbreak, but can lessen the severity of the disease
- Inactivated vaccines: intranasal/intramuscular administration
- gE deletion makes this a marker vaccine
- ELISA for gE deletion can enable culling of carrier animals
- Two live attenuated vaccines are available in the UK, one is temperature-sensitive
- IPV has mostly been made obsolete by AI