Difference between revisions of "Dermatophytosis"

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*Dermatophytes in [[Mycotic skin infections - Pathology#Dermatophytoses|dermatophytosis]]
 
*Dermatophytes in [[Mycotic skin infections - Pathology#Dermatophytoses|dermatophytosis]]
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[[Image: Microsporum canis lesions.jpg|100px|thumb|right|<small><center>''Microsporum canis'' alopecia and scaling lesions (Courtesy of Bristol BioMed Image Archive)</center></small>]]
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[[Image: Ringworm dog.jpg|100px|thumb|right|<small><center>Ringworm in a dog (Courtesy of Bristol BioMed Image Archive)</center></small>]]
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[[Image: Trichophyton mentagrophytes dog.jpg|100px|thumb|right|<small><center>Trichophyton mentagrophytes in a dog (Courtesy of Bristol BioMed Image Archive)</center></small>]]
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*Caused by [[Fungi|dermatophytes]]
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**''Microsporum'' - zoophilic
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**''Trichophyton'' - geophilic
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**''Epidermophyton'' - anthropophilic
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*Common in many species, especially cats
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*Hot, humid environment predisposes and viable fungi peripherally
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*More common in young animals
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*Produce proteolytic enzymes to penetrate surface lipid
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*Fungal hyphae invade keratin -> break into arthrospores
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*Epidermal hyperplasia ([[Skin Glossary - Pathology|hyperkeratosis, parakeratosis, acanthosis]]) and inflammation
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*Superficial perivascular dermatitis -> exocytosis (migration through epidermal layers) -> intracorneal microabscesses
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*Exocytosis -> folliculitis -> furunculosis
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*Highly variable lesions
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*Normal -> eruptive nodular -> pseudomycetoma -> onychomycosis
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*Grossly:
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**Circular or irregular lesion, may coalesce
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**Scaly to crusty patches
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**Alopecia due to broken hair shafts and hairs lost from inflammed follicles
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**Follicular papules and pustules
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**Peripheral red ring ('''ringworm''') due to dead fungi in areas of inflammation at centre of lesions and viable fungi peripherally
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*Microscopically:
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**Perifolliculitis, folliculitis or furunculosis
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**Epidermal hyperplasia
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**Intracorneal microabscesses
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**Septate hyphae or spores may be found in stratum corneum and keratin of hair follicles

Revision as of 16:58, 23 April 2009



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FUNGI



Dermatiaceous fungi

Microsporum canis alopecia and scaling lesions (Courtesy of Bristol BioMed Image Archive)
Ringworm in a dog (Courtesy of Bristol BioMed Image Archive)
Trichophyton mentagrophytes in a dog (Courtesy of Bristol BioMed Image Archive)
  • Caused by dermatophytes
    • Microsporum - zoophilic
    • Trichophyton - geophilic
    • Epidermophyton - anthropophilic
  • Common in many species, especially cats
  • Hot, humid environment predisposes and viable fungi peripherally
  • More common in young animals
  • Produce proteolytic enzymes to penetrate surface lipid
  • Fungal hyphae invade keratin -> break into arthrospores
  • Epidermal hyperplasia (hyperkeratosis, parakeratosis, acanthosis) and inflammation
  • Superficial perivascular dermatitis -> exocytosis (migration through epidermal layers) -> intracorneal microabscesses
  • Exocytosis -> folliculitis -> furunculosis
  • Highly variable lesions
  • Normal -> eruptive nodular -> pseudomycetoma -> onychomycosis
  • Grossly:
    • Circular or irregular lesion, may coalesce
    • Scaly to crusty patches
    • Alopecia due to broken hair shafts and hairs lost from inflammed follicles
    • Follicular papules and pustules
    • Peripheral red ring (ringworm) due to dead fungi in areas of inflammation at centre of lesions and viable fungi peripherally
  • Microscopically:
    • Perifolliculitis, folliculitis or furunculosis
    • Epidermal hyperplasia
    • Intracorneal microabscesses
    • Septate hyphae or spores may be found in stratum corneum and keratin of hair follicles