Difference between revisions of "Category:Liver - Degenerative Pathology"

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(Created page with '==Liver, Hydropic Degeneration== ==Hepatic lipidosis - fatty liver syndrome== *also known as lipid mobilisation syndrome *any persistent abnormal accumulation of fat withi…')
 
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==[[Liver, Hydropic Degeneration]]==
 
==[[Liver, Hydropic Degeneration]]==
  
 +
[[Hepatic Lipidosis]]
  
 
==Hepatic lipidosis - fatty liver syndrome==
 
*also known as lipid mobilisation syndrome
 
*any persistent abnormal accumulation of fat within [[Liver - Anatomy & Physiology|liver]] cells
 
*associated with
 
**dietary factors: obesity and starvation
 
**increased demand for energy: pregnancy, lactation, and starvation in physiological states
 
**''[[DM|Diabetes mellitus]]'', ketosis, and pregnancy toxaemia in pathological conditions
 
**abnormal hepatocytic function: prevents fatty acids from forming complexes with proteins to form low density lipoproteins for secretion into the blood
 
*enlarged [[Liver - Anatomy & Physiology|liver]] with round edges
 
*lightish yellow in colour
 
*cut surface is uniform and greasy to handle
 
 
The following are several important specific diseases in which fatty change is the main finding:
 
 
 
===associated with obesity===
 
Overfeeding will lead to the accumulation of fat in the [[Liver - Anatomy & Physiology|liver]]
 
 
This is a normal physiological function but if a sudden check in dietary intake is imposed it may tip such an animal into serious ill health
 
====Bovine====
 
*fat cow syndrome (extreme form of fatty liver)
 
*occurs in well-fed dairy cows a few days postpartum
 
*an excessive accumulation of liver fat without being able to export it from the [[Liver - Anatomy & Physiology|liver]] (during late dry period and early lactation)
 
*amount of fat deposited influenced by:
 
**Body Condition Score (how fat the cow is)
 
**Milk Yield (energy requirement)
 
**Appetite (low in fat cows)
 
*triggered by various conditions:
 
**abomasal displacement
 
**mastitis
 
**metritis
 
**retained [[Gestation -Placenta - Anatomy & Physiology|placenta]]
 
*can be fatal due to [[Liver - Anatomy & Physiology|liver]] failure (up to 25% has been reported)
 
 
=====Clinical=====
 
*cow is sick
 
*poor appetite
 
*excessive weight loss
 
*downer
 
*high incidence of post parturient disease
 
 
=====Gross=====
 
*fat infiltration of [[Liver - Anatomy & Physiology|liver]]
 
*enlarged
 
*rounded edges
 
*pale yellow colour
 
*friable
 
 
NB: will also get fat infiltration of [[Liver - Anatomy & Physiology|liver]] in cows which have not been eating for several days so interpret carefully
 
 
=====Prevention=====
 
*dry off cows at correct BCS (up to 3.5)
 
*do not adjust BCS during dry period
 
*do not starve fat dry cows
 
*maintain appetite over late dry and calving period to prevent excessive weight loss and fat mobilisation
 
*use transistion diet
 
 
====Feline====
 
*feline fatty [[Liver - Anatomy & Physiology|liver]] syndrome
 
*fairly similar and associated solely with obesity
 
*diagnosis on cytology/histopathology
 
*Survival rate is only 50-60%
 
*Pathophysiology:
 
**Incompletely understood
 
**Obese cats that lose 30-40% of body weight exhibit a similar syndrome to naturally occurring hepatic lipidosis
 
**But many causative factors for naturally occurring hepatic lipidosis:
 
***Peripheral lipolysis secondary to absolute or relative lack of insulin
 
***Protein-calories malnutrition
 
***Amino acid deficiencies – inability to synthesize apolipoproteins necessary to mobilize hepatic fat
 
***Deficiency of lipotrophic compounds
 
***Error of fatty acid oxidation
 
***Hepatic perioxosomal damage due to oxidative stress
 
*Cats with hepatic lipidosis have higher nonesterified fatty acids (NEFAs) compared to controls and those with cholangiohepatitis
 
**NEFAs are derived from lipolysis of fat stores and enter the [[Liver - Anatomy & Physiology|liver]]
 
**They are oxidized in the [[Liver - Anatomy & Physiology|liver]] for energy or converted to phospholipids or cholesterol or reesterified to triglycerides
 
**Limited increase in lipoprotein synthesis and secretion of triglycerides in VLDLs
 
**Capacity for increase in oxidation by mitochondria and ketone body synthesis is low
 
**Rate of fatty acid esterification to triglycerides is not limited so can lead to a marked increase in the accumulation of stored hepatic triglycerides
 
*Also all triglyceride accumulation in hepatocytes in these cats comes from mobilized peripheral adipose stores during nutritional stress
 
**high levels of triglyceride concentrations in the [[Liver - Anatomy & Physiology|liver]] will cause:
 
***severe periacinar necrosis
 
***jaundice
 
***hepatic encephalopathy
 
***high mortality rate
 
*Lipolysis – under control of hormone-sensitive lipase  hydrolyses triglycerides to NEFAs and glycerol
 
**Insulin – inhibits it
 
*Catecholamines (eg: released in stress, etc – neural input), glucocorticoids, thyroxine, GH and glucagons all promote lipolysis
 
*Lower insulin levels in cats with hepatic lipidosis or cholangiohepatitis compared to controls; and lower glucogon:insulin ratio in diseased cats
 
**But as not lipidosis specific, not likely to be the main factor involved
 
*Higher serum triglycerides in lipidotic cats compared to controls
 
  
 
====Equine hyperlipidemia====
 
====Equine hyperlipidemia====

Revision as of 12:51, 7 June 2010

Liver, Hydropic Degeneration

Hepatic Lipidosis


Equine hyperlipidemia

  • fat pony syndrome
  • occurs exclusively in fat ponies especially fat Shetland ponies
  • more susceptible if pregnant and lactating
  • may be triggered by some reduction in feed intake
  • Clinical signs
    • dullness
    • colic
    • anorexia
    • hepatic encephalopathy
    • mania (sometimes)

NB: similar to that in cats, as well as fatal (within a week)

Ovine White Liver Disease

  • Australia and Europe
  • young lambs on lush pasture
  • clinical signs
    • ill thrift
    • anorexia
    • jaundice
    • photosensitisation
  • treatment
    • responsive to Vitamin B12 and cobalt

associated with derangement of carbohydrate metabolism

Diabetes mellitus

  • where there is insufficient insulin or a decrease in number of insulin receptors in cells
  • seen mostly in dogs
  • produces a markedly fatty liver due to release of fat from the fat stores for use as an energy source

Ketosis

  • due to an excessive drain on carbohydrate stores because pregnant and lactating animals have a continuous demand for glucose
  • ketosis results when fat metabolism which occurs in response to the increased energy demand is excessive
  • ketone bodies accumulate in the blood and there is marked fatty change in the liver
  • can occur in starvation but commonly seen in two conditions in livestock:
ketosis of cattle (acetonemia)
  • occurs in high yielding dairy cows a few weeks postpartum
  • due to excessive loss of glucose in the milk
  • milk yield drops
  • smell of ketones on the breath
  • ketones excreted in the milk
  • self-limiting condition
pregnancy toxaemia in sheep
  • occurs in ewes in late pregnancy carrying twin lambs 'twin lamb disease'
  • drain of carbohydrate stores is due to rapidly growing foetuses
  • serious condition and highly fatal
  • clinical signs (neurological)
    • apparent blindness
    • dullness
    • convulsions
    • coma
  • sequelae
    • foetuses die
    • apparent recovery in ewe until toxaemia from the decomposing foetuses results in the ewe's death


associated with anoxia and toxaemia

anoxia

  • passive congestion
  • anaemias

toxaemia

  • toxins absorbed from the gut interfere with many stages of triglyceride metabolism

Pages in category "Liver - Degenerative Pathology"

The following 9 pages are in this category, out of 9 total.