Difference between revisions of "Endocrine Pancreas - Pathology"
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[[Insulinoma]] | [[Insulinoma]] | ||
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===Gastrinoma=== | ===Gastrinoma=== | ||
[http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] | [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Image&imgID=7762 Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine] | ||
Revision as of 13:39, 9 June 2010
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Pancreas, Endocrine - Degenerative Pathology
Neoplasia
Insulin Secreting Neoplasms
Carcinomas
Gastrinoma
Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine
- Described in dogs, cats
- Known as Zollinger-Ellison syndrome in humans
- Uncommon compared to beta cell neoplasms
- Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration
Clinical signs
Pathology
- Multiple variably sized neoplasms
- Increased connective tissue mass - firm
- Partiallty encapsulated
- Invade locally
- Metastases to liver and local lymph nodes are common
Glucagonoma
- Very rare
- Characterised by
- Hyperglycaemia
- Vacuolar hepatopathy
- Skin erythema with superficial necrotising dermatitis
- Diagnosis in dogs is difficult as presents together with DM