Difference between revisions of "Infectious Canine Hepatitis"
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| + | |Also known as: | ||
| + | |Rubarth's Disease <BR> Canine adenovirus infection | ||
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*adenovirus - [[Canine Adenovirus 1]] | *adenovirus - [[Canine Adenovirus 1]] | ||
*also known as Rubarth's Disease, Canine adenovirus infection | *also known as Rubarth's Disease, Canine adenovirus infection | ||
Revision as of 14:25, 5 July 2010
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This article is still under construction. |
| Also known as: | Rubarth's Disease Canine adenovirus infection |
- adenovirus - Canine Adenovirus 1
- also known as Rubarth's Disease, Canine adenovirus infection
- acute and generalised infection
- young dogs
- highly infectious
- spread via the urine of infected animals over a long period of time
Clinical
- lymph nodes and tonsils are enlarged and reddened, sometimes haemorrhagic
- recovering animals may show an immune-mediated uveitis with corneal opacity
Gross
- the virus has a tropism for endothelium and hepatocytes
- widespread haemorrhages, especially on serosal surface
- distinctly pale mottled appearance
- from extensive necrosis, characteristically periacinar (centrilobular) in distribution - the reason for the increased susceptibility of this area is not known
- enlarged
- friable
- fibrinous or fibrino-haemorrhagic strands between lobes
- gall bladder
- wall usually shows oedema (up to 2cm diameter)
Microscopically
- basophilic intranuclear inclusion bodies
- in hepatocytes and macrophages