Difference between revisions of "Equine Severe Combined Immune Deficiency"
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m (Text replace - "[[Lymphocytes|" to "[[Lymphocytes - Introduction|") |
m (Text replace - "Category:To Do - Blood" to "Category:To Do - BloodCategory:To Do - Clinical") |
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*Foals usually die from bronchopneumonia | *Foals usually die from bronchopneumonia | ||
[[Category:Primary Adaptive Immunity Deficiencies]] | [[Category:Primary Adaptive Immunity Deficiencies]] | ||
| − | [[Category:To Do - Blood]] | + | [[Category:To Do - Blood]][[Category:To Do - Clinical]] |
[[Category:Horse]] | [[Category:Horse]] | ||
Revision as of 10:54, 20 August 2010
(Equine SCID)
- Autosomal recessive
- Occurs in 2-3% of Arabian foals
- Defect in DNA-dependent protein kinase gene
- Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
- No functional B cells or T cells
- Foals develop infections (usually around 8 weeks of age as maternal antibody in colostrum wanes around this time)
- Foals usually die from bronchopneumonia