Category:Enteritis, Villus Atrophy
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Villus Atrophy
- Commonly seen in enteric disease.
- Occurs when more enterocytes are lost than are produced in the crypts.
- Causes malabsorption of nutrients and water.
- There are two main types of villus atrophy:
Villus atrophy with intact/hypertrophic crypt glands
Villus atrophy with damage to crypts
- The primary insult is to crypt cells.
- Crypt cell death leads to dilated gland lumens (cysts).
- Production is impaired, eventually leading to insufficient cells for villi.
- Enterocytes lost to lumen are replaced by increasingly immature cells.
- Gives rise to severe malabsorption.
- If damage is severe, erosions/ulcers may form which may eventually heal.
- Even if there are no ulcers, damage can be long-term
- Causes long-term malabsorption.
- Even if there are no ulcers, damage can be long-term
- Examples include:
- Parvovirus
- Target crypt cells.
- Lymphoma
- Numerous neoplastic lymphocytes compress crypts.
- Cytotoxic chemicals
- Dividing crypt cells are susceptible.
- Parvovirus
Enteritis Particularly Associated with Villus Atrophy
Rotavirus
Cryptosporidium
Pages in category "Enteritis, Villus Atrophy"
The following 5 pages are in this category, out of 5 total.