Gastrinoma

Image of pancreatic garstrinoma in a dog from Cornell Veterinary Medicine

• Described in dogs, cats
• Known as Zollinger-Ellison syndrome in humans
• Uncommon compared to beta cell neoplasms
• Excess gastrin causes hyperacidity in the stomach and mucosal hyperplasia of the antral region causing gastric and duodenal ulceration

Clinical signs

• Anorexia
• Severe weight loss
• Vomiting
• Diarrhoea
• Dehydration

Pathology

• Multiple variably sized neoplasms
• Increased connective tissue mass - firm
• Partiallty encapsulated
• Invade locally
• Metastases to liver and local lymph nodes are common