Hepatic Encephalopathy - Horse

Description

Hepatic encephalopathy is neurological disfunction caused by any acute or severe hepatic damage; 60-80% of hepatic function must be lost before clinical signs develop. A combination of mechanisms is probably responsible for the syndrome.

Signalment

No age, sex or breed predisposions.

There are many hepatic disorders which can lead to hepatic encephalopathy including, Hepatitis, Ragwort Toxicity, Tyzzer's Disease and Hyperlipaemia

Diagnosis

Clinical Signs

Clinical signs vary depending on the severity of hepatic dysfunction, early signs are often subtle and may be missed. Clinical signs may be associated with feeding.

Depression
Lethargy
Head pressing
Dysphagia
Ataxia
Behavioural changes
Seizures
Coma
Death

Clinical signs associated with hepatic disease

Weight loos
Diarrhoea
Icterus

Laboratory Tests

Haemotology and Biochemistry results will be consistent with hepatic disease; including increased GGT and SDH, hypoalbuminaemia and elevated bile acids.

Biopsy

A liver biopsy can provide a definitive diagnosis of liver disease, a clotting profile should be carried out before taking an ultrasound-guided biopsy.

Ultrasound

Transabodimal ultrasound can be used to assess the structure of the liver and degree of damage.

Pathology

See Hepatic Encephalopathy Pathology

Treatment

With supportive therapy horses may recover from hepatic encephalopathy after 4-21 days. Treatment is only warranted in acute cases likely to make a recovery.

Sedation is often necessary in cases of hepatic encephalopathy; An alpha 2 agonist at a low dose is usually effective. If the neurological signs are so severe that the horse is a danger to itself and others then immediate euthansia is indicated.

Fluid deficits and acid base abnormalities should be corrected as necessary and hypoglycaemic animals should be given a 5% dextrose solution IV. High carbohydrate, low protein diets should be fed in small amounts fequently.

Prognosis

Prognosis is poor to severe but depend on the underlying disease; signs are potentially reversible if the initiating course can be corrected. Horses with hepatic disease showing neurological signs have a poorer prognosis than those showing only signs af hepatic dysfunction. However with appropriate supportive therapy 40% of horses survive for at least 6 months. Recovery may be incomplete and temporary.

References

Bertone, J. (2006) Equine Geriactric Medicine and Surgery, Elsevier
Knottenbelt, D.C. A Handbook of Equine Medicine for Final Year Students University of Liverpool
Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
Rose, R. J. and Hodgson, D. R. (2000) Manual of Equine Practice (Second Edition) Sauders.