Central Nervous System Inflammation Overview
Central Nervous System Infectious Inflammation
Category:CNS Non-Infectious Inflammatory Diseases
Granulomatous Meningoencephalitis
(GME)
- An idiopathic CNS conditon
- May occur as:
- A disseminated disease
- A focal mass lesion
- A primary occular disease
- Brainstem signs are common, although the forebrain is primarily affected.
- May be incorrectly diagnosed as lymphoma.
- Changes are apparent in the CSF.
- There is usually a mononucloear pleocytosis.
- Sometimes only protein is elveated.
- Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
- However, biopsy is required for a definative diagnosis.
- Life span is between 6 months and 1 year from diagnosis.
Treatment
- Immunosuppression:
- Corticosteroids
- Azathioprine
- Cycophosphamide
- Surgery
- This is only appropriate if there is a focal mass.
- Radiation therapy.
Necrotising Meningoencephalitis
Category:CNS Non-Infectious Inflammatory Diseases
Pug Encephalitis
- A CNS idiopathic condition
- Affects pugs.
- Similar conditions are seen in yorkshire and maltese terriers.
- Officially known as necrotising meningoencephalitis of small dogs.
- Characterised by histological forebrain inflammation and necrosis.
- The disease is uniformly fatal.
- Corticosterid treatment has no effect.
[:Category:CNS Non-Infectious Inflammatory Diseases]]