CNS Inflammation - Pathology

Central Nervous System Inflammation Overview


Central Nervous System Infectious Inflammation



Category:CNS Non-Infectious Inflammatory Diseases

Granulomatous Meningoencephalitis

(GME)
  • An idiopathic CNS conditon
  • May occur as:
    • A disseminated disease
    • A focal mass lesion
    • A primary occular disease
  • Brainstem signs are common, although the forebrain is primarily affected.
  • May be incorrectly diagnosed as lymphoma.
  • Changes are apparent in the CSF.
    • There is usually a mononucloear pleocytosis.
    • Sometimes only protein is elveated.
  • Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
    • However, biopsy is required for a definative diagnosis.
  • Life span is between 6 months and 1 year from diagnosis.

Treatment

  • Immunosuppression:
    • Corticosteroids
    • Azathioprine
    • Cycophosphamide
  • Surgery
    • This is only appropriate if there is a focal mass.
  • Radiation therapy.

Necrotising Meningoencephalitis

Category:CNS Non-Infectious Inflammatory Diseases


Pug Encephalitis

  • A CNS idiopathic condition
  • Affects pugs.
    • Similar conditions are seen in yorkshire and maltese terriers.
  • Officially known as necrotising meningoencephalitis of small dogs.
  • Characterised by histological forebrain inflammation and necrosis.
  • The disease is uniformly fatal.
    • Corticosterid treatment has no effect.


[:Category:CNS Non-Infectious Inflammatory Diseases]]