Porcine Adenovirus

Also Known As: pADV 1-5 — pADV A-C

Introduction

Porcine adenovirus causes diarrhoea and gastrointestinal disease in piglets and also often being implicated in multifactorial respiratory diseases.

pADV-4 is thought to be the most pathogenic of the porcine adenoviruses.

Distribution

Worldwide

Transmission is faecal:oral

Signalment

pADV is only known to affect swine.

Clinical Signs

pADV is a low grade pathogen, associated with short duration mild clinical signs.

Diarrhoea, inappetance, dehydration and anorexia often present in various degrees of severity.

Dullness, depression, lethargy, listlessness and tremors may develop, often secondary to dehydration.

Reproductive disease may present as abortion and stillbirth pigs.

Respiratory disease, e.g. cough, dyspnoea, blue extremities etc. often develops when combined with other pathogens.

Subclinical and asymptomatic infections are common.

Diagnosis

Histologically, pADV causes formation of nuclear inclusion bodies in the intestinal cells.

Viral isolation can be performed in tissue cultures. Cells infected become rounded and enlarged and then detach from the vessel.

Viral particles can be seen via electron microscopy up to 6 days post infection.

Immunoperoxidase and immunofluorescent staining can demonstrate viral antigen.

Antibodies can be detected serologically with immunodiffusion, complement fixation, serum neutralisation and ELISA.

Treatment

None is usually necessary as disease is mild and/or transient.

Control

None is usually practised although a study has demonstrated beneficial use of a vaccine

Porcine Adenovirus Learning Resources
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References

Animal Health & Production Compendium, Porcine Adenovirus datasheet, accessed 16/06/2011 @ http://www.cabi.org/ahpc/

Animal Health & Production Compendium, Porcine Adenovirus infection datasheet, accessed 16/06/2011 @ http://www.cabi.org/ahpc/