Also Known As: pADV 1-5 — pADV A-C
Porcine adenovirus causes diarrhoea and gastrointestinal disease in piglets and is also often implicated in multifactorial respiratory diseases.
pADV-4 is thought to be the most pathogenic of the porcine adenoviruses.
Transmission is faecal:oral
pADV is only known to affect swine.
pADV is a low grade pathogen, associated with short duration mild clinical signs.
Diarrhoea, inappetance, dehydration and anorexia often present in various degrees of severity.
Dullness, depression, lethargy, listlessness and tremors may develop, often secondary to dehydration.
Reproductive disease may present as abortion and stillbirth pigs.
Respiratory disease, e.g. cough, dyspnoea, blue extremities etc. often develops when combined with other pathogens.
Subclinical and asymptomatic infections are common.
Histologically, pADV causes formation of nuclear inclusion bodies in the intestinal cells.
Viral isolation can be performed in tissue cultures. Cells infected become rounded and enlarged and then detach from the vessel.
Viral particles can be seen via electron microscopy up to 6 days post infection.
Immunoperoxidase and immunofluorescent staining can demonstrate viral antigen.
None is usually necessary as disease is mild and/or transient.
Affected animals can become dehydrated and so symptomatic treatment with fluid replacement solutions is recommended.
None is usually practised although a study has demonstrated beneficial use of a vaccine
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- Buller, C. R., Moxley, R. A. (1988) Natural infection of porcine ileal dome M cells with rotavirus and enteric adenovirus. Vet Path, 25(6):516-517; 9
- Kadoi, K (1997) Beneficial use of inactivated porcine adenovirus vaccine and antibody response of young pigs. New Microbiol. 20:89-91
The datasheet was accessed on 16 June 2011.
This article has been expert reviewed by Dr Mandy Nevel
Date reviewed: 09 September 2011
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