Uraemia

Description

Uraemia describes the clinical systemic syndrome that occurs in animals suffering from renal failure. Traditionally, uraemia was thought to caused by caused by azotaemia, an increase in the blood concentrations of urea and creatinine, but it is now apparent that multiple uraemic toxins cause derangements in many metabolic processes. Azotaemia is important in the diagnosis of uraemia but it is an insensitive indicator of renal failure, only becoming detectable when more than approximately two thirds of the nephrons are no longer functional.

Pathophysiology

The kidney has multiple metabolic functions, removing nitrogenous waste from the plasma, maintaining electrolyte and acid/base balance and producing hormones such as erythropoietin (EPO). Renal failure causes alterations in all of these functions causing the clinical signs of uraemia.

Failure to excrete nitrogenous waste leads to azotaemia and, although this term refers specifically to urea and creatinine cocnentrations, multiple other forms of waste are retained and contribute to the clinical syndrome. The nitrogenous waste causes pathological changes of arteriolar fibrinoid degeneration throughout the body.

Other uraemic toxins include parathyroid hormone (PTH), phosphate, insulin, gastrin, glucagon and prolactin. PTH is released due to hypocalcaemia caused by phosphate retention and reduced production of vitamin D and its effects produce secondary renal hyperparathyroidism.

Signalment

Uraemia is described almost exclusively in animals with renal failure.

Diagnosis

Clinical Signs

Lesions due to uraemia associated with pyelonephritis and chronic kidney disease
Copyright Alun Williams 2007 (RVC))

Uraemia is a complex disorder that affects multiple organ systems and produces a variety of clinical syndromes:

Gastro-intestinal Disease

• Oral ulceration - This occurs especially at the fauces of the mouth and on the margins of the tongue. Halitosis is often a feature of this syndrome as the lesions become secondarily infected with oral bacteria such as Fusobacterium necrophorum. In severe cases, there may be extensive subepithelial necrosis and sloughing of the tip of the tongue. The lesions are often very painful and contribute to the anorexia often observed in animals with chronic kidney disease. Excessive dental calculus may be evident in animals with chronic kidney disease on oral examination.
• Gastric ulceration - This occurs for three main reasons. First, urea crosses lipid membranes freely and enters the gastro-intestinal lumen of azotaemic animals. The urea is degraded to ammonia by bacterial urease and the ammonia irritates the intestinal mucosa. This is compounded by damage to the blood vessels of the gastric submucosa by the fibrinoid necrosis that is a common feature of uraemia. Elevated serum concentrations of gastrin (which is normally metabolised in the kidney) also lead to excessive production of gastric acid from parietal cells in the stomach. Animals with gastro-duodenal ulceration may show anorexia, vomiting, haematemesis and peritonitis and haemorrhage if the ulcers perforate. Hypergastrinaemia may also cause incompetence of the pyloric sphincter of the stomach, permitting relfux of irritant bile into the stomach. Similar processes result in the development of uraemic colitis.
• Uraemic peritonitis - This is a form of chemical peritonitis that results from inflammation of the small mesothelial blood vessels.

Respiratory Disease

• Pulmonary oedema - Damage to the small vessels of the pulmonary vasculature may result in the development of vasogenic pulmonary oedema and pleural effusion with dyspnoea, tachypnoea and coughing.

Electrolyte and Acid/Base Imbalances

• Electrolyte imbalances - The failure to excrete phosphate through the damaged kidneys results in hyperphosphataemia. This electrolyte complexes with calcium and also prevents the activation of vitamin D (dihydroxycholecalciferol), resulting in hypocalcaemia. This hypocalcaemia directly stimulates the production of parathyroid hormone (PTH) to try to maintain normal blood calcium levels and, in ~10% dogs with renal failure, hypercalaemia may develop due to an alteration in the set-point at which PTH is secreted. In the remaining 90%, calcium is mobilised from bone causing secondary renal hyperparathyroidism with resorption of bone, pathological fractures and fibrous osteodystrophy of the bones of skull ('rubber jaw').
• Metastatic mineralisation - The presence of excessive blood concentrations of phosphate leads to metastatic calcification in multiple tissues, particularly the rugae of the gastric mucosa, the pulmonary parenchyma and the heart.
• Metabolic acidosis - The kidney plays a vital role in the regulation of the normal acid/base balance.

Cardiovascular Disease

• Atrial rupture - Mineralisation of the atria reduces their normal compliance and renders them susceptible to rupture. The resultant haemopericardium is often fatal as it causes acute cardiac tamponade.
• Arrhthymias

Haematological Disease

• Thrombocytopathia - The reduction in platelet function occur due to multiple alterations in normal thrombocyte metabolism.
• Anaemia - This occurs because the diseased kidenys produce less erythropoietin than normal and the uraemic toxins (especially PTH) decrease the lifespan of existing red blood cells. Erythrocytes may also be damaged as they pass along inflamed vessel walls, a form of microangiopathic haemolysis. Chronic gastro-intestinal haemorrhage may also result in iron deficiency.

Neuromuscular Disease

• Neurological disease - The presence of extremely high concentrations of urea and creatinine may induce reduced conciousness or uraemic seizures and this is usually a terminal event. PTH has also been implicated in the development of uraemic encephalopathy, possibly due to alterations in calcium pumps. Animals may enter a so-called twitch-convulsive state where they suffer concurrent tremors, myoclonus and seizures. Peripheral neuropathies may contribute to the reduced hindlimb function that is commonly ascribed to hypokalaemic myopathy.
• Myopathy - Hypokalaemic animals with chronic kidney disease may suffer severe muscle weakness with a plantigrade stance and cervical ventroflexion in cats which lack a nuchal ligament.

Laboratory Tests

Serum biochemistry will show elevated levels of urea and creatinine. Animals with acute renal failure may by hyperkalaemic and hyperphosphataemic but cats with chronic renal failure are often hypokalaemic, hyperphosphataemic and hyponatraemic. Blood ionised calcium concentration may be reduced (in ~90% cases) or elevated (in ~10% cases).

In cases of chronic renal failure, there may be a normocytic, normochromic, non-regenerative anaemia. Platelet levels are usually normal despite any reduction in function.

Other Tests

Examination of a urine sample may show signs consistent with renal failure. Animals with acute renal failure may be anuric and those with chronic renal failure may be polyuric but in both cases, the urine will be isosthenuric (with a specific gravity of 1.008-1.012).

Diagnostic Imaging

Imaging may show the presence of metastatic calcification in multiple organs, including...

Animals with secondary renal hyperparathyroidism may show resorption of bone from the skull (particularly the alveolar bone and lamina dura around the teeth) and the terminal phalanges.

Other Tests

Uraemic carcases?

Treatment

The underlying cause of the renal failure should be treated. To alleviate the clinial signs of uraemia, it is particularly important to restrict phosphate by feeding a low phosphate diet and using phosphate-binding drugs such as aluminium hydroxide or chitosan. Deficient electroylytes should be supplemented but calcium should only be administered after hyperphosphataemia has been corrected to prevent further mineralisation of soft tissues.

A major advance in the management of uraemia has been the introduction of recombinant erythropoietin which can be administered to anaemic animals as a series of subcutaneous injections. Some animals may become resistant to its effects over time due to the development of an immune response to the recombinant protein.

Prognosis

Renal failure that is sufficiently severe to cause uraemia is very severe and carries a poor prognosis for recovery. Lost renal function cannot be recovered and the best that can be hoped for is to manage the clinical syndrome as long as the patient maintains an acceptable quality of life.