Equine Motor Neuron Disease

Generalised LMN disorder

Degeneration of Ventral horn motor neuron

Chromatolysis

Neurofilament accumulation

Gliosis

Wallerian degeneration

Denervation changes in muscle

Weight Loss

Muscle atrophy

Generalised Weakness

Short strided gait + narrow based stance

Trembling

Sweating and fasiculations

Increased recumbency

Elevated CK

CSF protein

Denervation of EMG

May progress to constant recumbency (destroy), stabilise or improve