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*Limited array of ways in which to respond to injury
 
*Limited array of ways in which to respond to injury
**[[Muscles Degenerative - Pathology#Degeneration|Degeneration]]
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**[[:Category:Muscles - Degenerative Pathology|Degeneration]]
**[[Muscles Degenerative - Pathology#Necrosis|Necrosis]]
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**[[Muscle Necrosis|Necrosis]]
 
**Regeneration
 
**Regeneration
**[[Muscles Degenerative - Pathology#Atrophy|Atrophy]]
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**[[Muscle Atrophy|Atrophy]]
 
**[[Muscles Hyperplastic and Neoplastic - Pathology#Hypertrophy|Hypertrophy]]
 
**[[Muscles Hyperplastic and Neoplastic - Pathology#Hypertrophy|Hypertrophy]]
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**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur
 
**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur
 
*Stages:
 
*Stages:
#Nuclei in [[Muscles Degenerative - Pathology#Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscles Degenerative - Pathology#Calcification|mineralise]]
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#Nuclei in [[Muscle Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscle Calcification|mineralise]]
 
#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)
 
#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)
 
#Satellite cells move to centre
 
#Satellite cells move to centre
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*Regeneration by '''budding'''
 
*Regeneration by '''budding'''
 
**When conditions are not optimal, disrupted sacrolemma
 
**When conditions are not optimal, disrupted sacrolemma
**E.g. injection of irritating substance, trauma, [[Muscles Degenerative - Pathology#Ischaemia|infarction]]
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**E.g. injection of irritating substance, trauma, [[Muscle Ischaemia|infarction]]
 
**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells
 
**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells
 
*Monophasic lesions - all at same phase above
 
*Monophasic lesions - all at same phase above
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