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When [[Phagocytosis|phagocytosis]] of the bacteria or fungi by the tissue macrophages occurs they release a number of [[Cytokines|cytokines]] that have a number of effects. The first being the activation of the endothelium that results in the expression of adhesion molecules that allow leukocytes, in particular the [[Neutrophils|neutrophils]] to bind to the endothelium from the bloodstream and the subsequent [[Neutrophils|extravasation]] (movement out of the bloodstream). Once the leukocytes are out of the bloodstream, the cytokines released by the tissue macrophages act as chemoattractants that enable the chemotaxis of the leukocytes to the site of infection.   

When [[Phagocytosis|phagocytosis]] of the bacteria or fungi by the tissue macrophages occurs they release a number of [[Cytokines|cytokines]] that have many effects. The first being the activation of the endothelium that results in the expression of adhesion molecules that allow leukocytes, in particular the [[Neutrophils|neutrophils]] to bind to the endothelium from the bloodstream and the subsequent [[Neutrophils|extravasation]] (movement out of the bloodstream). Once the leukocytes are out of the bloodstream, the cytokines released by the tissue macrophages act as chemoattractants that enable the chemotaxis of the leukocytes to the site of infection.   

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