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*Vaccination of lambs with toxoid before 2 months of age to protect against pulpy kidney
 
*Vaccination of lambs with toxoid before 2 months of age to protect against pulpy kidney
 
*Avoid sudden dietary changes
 
*Avoid sudden dietary changes
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===''C. piliforme''===
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*Spore-forming filamentous Gram negative intracellular pathogen
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*Only grows in tissue culture or embryonated eggs
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*Causes Tyzzer's disease - severe hepatic necrosis
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*Sporadic disease in foals, calves, dogs, cats
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*Foals under 6 weeks, found dead or comatose
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*Incubation period up to 1 week
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*Depression, anorexia, fever, jaundice, diarrhoea
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*Hepatomegaly and necrosis on post mortem
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*Diagnosis: Warthin-Starry silver impregnation technique demonstrates organisms in hepatocytes
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===''C. difficile''===
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*Dogs with chronic diarrhoea
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*New born foals with haemorrhagic enterocolitis
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*Possibly associated with acute colitis in adult horses following antibiotic therapy or grain overload
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===''C. colinum''===
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*Enteritis in poulty and game birds
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*Shed in faeces of clinically affected and carrier birds
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*Intestinal ulceration and hepatic necrosis
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*Therapeutic antibiotics in drinking water
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===''C. spiroforme''===
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*Spontaneous and antibiotic-induced enteritis in rabbits
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*Enterotoxaemia, fatal within 48 hours
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*Oral antibiotics upset the intestinal flora, allowing overgrowth of clostridia
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