Changes

===Other Effects===

===Other Effects===

*The combination product (alfaxalone/aldalone) solubilised in Cremohpor EL has been associated with histamine release leading to swollen paws and face, erythema and anaphylactoid reactions in dogs and cats, also making it contraindicated in cats with asthma or mast cell tumours.  This is not experienced with the aqueous cyclodextrin formulation of alfaxalone

*Administration of the combination product (alfaxalone/aldalone) solubilised in Cremophor EL is associated with adverse effects. In cats hyperaemia or oedema of the ears and forepaws is observed in over half of animals; and in dogs it can induce an anaphylactoid reaction with histamine release leading to a fall in arterial blood pressure, urticaria and skin erythema. Its association with histamine release means it is contraindicated in animals with conditions such as asthma or mast cell tumours.   

 

These adverse effects are '''not''' experienced in cats or dogs following administration of the aqueous cyclodextrin formulation of alfaxalone, which is Cremophor-free.

==Uses==

==Uses==