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In cases where animals experience sedation or other unwanted side effects awareness of the intermediate metabolites can be essential. This is because when treated with the intermediate compound on its own animals may respond better, with fewer adverse side effects.
In cases where animals experience sedation or other unwanted side effects awareness of the intermediate metabolites can be essential. This is because when treated with the intermediate compound on its own animals may respond better, with fewer adverse side effects.
==Uses==
==Use==
*Licensed [dog]
*Licensed [dog]
:*Separation anxiety
:*Separation anxiety
:*Spraying where anxiety, especially chronic, is a factor [if problem is longstanding or refractory to behavioural treatment]
:*Spraying where anxiety, especially chronic, is a factor [if problem is longstanding or refractory to behavioural treatment]
:*Some narcopleptic disorders
:*Some narcopleptic disorders
Onset of action is 4 or more weeks. The dose of Clomipramine may need to be increased from an initial dose rate once daily, to a higher dose rate if initial response is insufficient after 6-8 weeks. Higher doses are associated with increased adverse effects such as sedation and it is important that genuine response to therapy is not confused with undesirable profound sedative effects which will suppress all sorts of behaviour.
Once the condition being treated is deemed under control drug therapy should be gradually phased out over approximately 4-8 weeks. This is preferable to stopping administration of a drug all at once and reduces potential central withdrawal signs, as well as allowing establishment of the lowest dose that is still effective if problem behaviour is resumed during the weaning process. Although treatments are long term, maintenance doses are generally significantly lower than doses used at the beginning of the treatment regime. Successful drug therapy should produce around 70% reduction in the behaviour and an increase in normal activity as a substitute.
==Adverse Effects==
==Adverse Effects==