Changes

==Mechanisms of Resistance==

==Mechanisms of Resistance==

This is still an area of research, but most methods of resistance seem to revolve around a reduced binding site affinity. For [[benzimidazoles]] it seems that there is less affinity to the tubulin binding site. [[Macrocyclic Lactones]] seem to have increased expression of a non-specific transmembrane efflux pump that can eject toxins out of thenematode.

This is still an area of research, but most methods of resistance seem to revolve around a reduced binding site affinity. For [[benzimidazoles]] it seems that there is less affinity to the tubulin binding site. [[Macrocyclic Lactones]] seem to have increased expression of a non-specific transmembrane efflux pump that can eject toxins out of the nematode.

 

==Investigating Resistance==

==Investigating Resistance==