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Immunodeficiencies - WikiBlood (view source)
Revision as of 11:42, 8 September 2008
, 11:42, 8 September 2008→Primary Immunodeficiency
==Primary Immunodeficiency==
==Primary Immunodeficiency==
*Primary immunodeficiencies may affect either the innate or adaptive immune system
*They are categorised by either the type or the developmental stage of the cells involved
*Lymphoid cell disorders affect T or B cells (or both)
*Myeloid cell disorders affect phagocytic function
*The severity of the immunodeficiency depends on at which stage in development the problem occurs
**E.g. Defects early on in development will affect the entire immune system
*A t cell deficiency can affect both the cell-mediated and humoral response as T cells play a central role in the immune system
===Deficiencies of Innate Immunity===
===Deficiencies of Innate Immunity===
*Arthymic nude mice (no thymus)
*Arthymic nude mice (no thymus)
**No functional T cells
**No functional T cells
**Cell-mediated immunodeficiency
*Knock-out mice
*Knock-out mice