Changes

* Trypanocidal drugs can be used for chemo-therapy/prophylaxis

* Trypanocidal drugs can be used for chemo-therapy/prophylaxis

* Resistance has been documented in donkeys (Assefa, 2001)

* Resistance has been documented in donkeys (Assefa, 2001)

* The drugs shown in <font color='green>Table 2 (page 281) </font color>have been suggested for equines. They should be used with great caution, preferably after determining the trypanosome chemosensitivity and as part of integral approach to the disease

* The drugs shown in the table below have been suggested for equines. They should be used with great caution, preferably after determining the trypanosome chemosensitivity and as part of integral approach to the disease

* Deep muscle injection divided through the day is recommended for some drugs, ''e.g.'' quinapyramine, because of tissue necrosis and toxicity. Adverse reactions are common with many trypanocides

* Deep muscle injection divided through the day is recommended for some drugs, ''e.g.'' quinapyramine, because of tissue necrosis and toxicity. Adverse reactions are common with many trypanocides

* Diminazene at therapeutic doses can produce severe nervous signs and sometimes death in donkeys. It has been used as a preventative at low dosage every three months. Its success with mules for surra has been documented, as has the mild to severe toxicity observed when it was used (Tuntasuvan, 2003)

* Diminazene at therapeutic doses can produce severe nervous signs and sometimes death in donkeys. It has been used as a preventative at low dosage every three months. Its success with mules for surra has been documented, as has the mild to severe toxicity observed when it was used (Tuntasuvan, 2003)