Changes

==Nomenclature and classification==

==Nomenclature and classification==

Nomenclature of the cytokines was first based on their activity both ''in vivo'' and ''in vitro'', with the name being abbreviated to acronyms. For example, when a factor isolated from antigen-activated lymphocytes was added to non-immune peritoneal macrophages, their migration from capillary tubes was inhibited. This led to the factor being named migration inhibition factor, or MIF for short. It was then discovered that many biological functions were being produced by the same chemicals, which led to the classification of cytokines based on either the cell populations that secrete them or their function:

Nomenclature of the cytokines was first based on their activity both ''in vivo'' and ''in vitro'', with the name being abbreviated to acronyms. For example, when a factor isolated from antigen-activated lymphocytes was added to non-immune peritoneal macrophages, their migration from capillary tubes was inhibited. This led to the factor being named migration inhibition factor, or MIF for short. It was then discovered that many biological functions were being produced by the same chemicals, which led to the classification of cytokines based on either the cell populations that secrete them or their function:

*'''Monokines'''- produced by myeloid cells (macrophages, monocytes)

*'''Monokines'''- produced by myeloid cells (macrophages, [[Monocytes - WikiBlood]])

*'''Lymphokines'''- produced primarily by lymphocytes

*'''Lymphokines'''- produced primarily by lymphocytes

*'''Interleukins'''- produced by leukocytes in general

*'''Interleukins'''- produced by leukocytes in general