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Yersinia (view source)

Revision as of 13:39, 12 May 2010

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===Overview===

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===Pathogenesis===

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*''Y. enterocolitica and [[Yersinia pseudotuberculosis|''Y. pseudotuberculosis'']] enter the intestinal mucosa via M cells of the Peyer's patches

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*[[Yersinia enterocolitica|''Y. enterocolitica'']] and [[Yersinia pseudotuberculosis|''Y. pseudotuberculosis'']] enter the intestinal mucosa via M cells of the Peyer's patches

*Engulfed by macrphages in the mucosa

*All three invasive species are facultative intracellular organisms and grow inside macrophages

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*''[[Yersinia pseudotuberculosis]]''

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**Less virulent than ''Y. pestis'' but closely related

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**Mainly infect animals

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**One plasmid, required for virulence

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**Sporadic cases of pseudotuberculosis in animals and man

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**Wild birds and rodents provide a reservoir of infection by harbouring the the pathogen in their intestinal tract

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**Sources include food and water contaminated by faeces

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**Pseudotuberculosis (caseous abscesses) in rodents, guinea pigs, cats, turkeys

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**Epidymo-orchitis in rams

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**Abortion in goats

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**Occasional infections in pigs, cattle, sheep

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**Multiplication in macrophages leads to granuloma formation

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**Granulomas occur in the gut wall and mesenteric lymph nodes

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**Occasional spread from the mesenteric lymph nodes to the liver and [[Spleen - Anatomy & Physiology|spleen]]

*''[[Yersinia enterocolitica]]''

**Pathogen of animals and humans

Bara

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