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Infectious Canine Hepatitis (view source)

Revision as of 15:50, 5 July 2010

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→‎Diagnosis

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==Diagnosis==

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*Intranuclear inclusion bodies in hepatocytes can be seen under H&E staining

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*Vascular endothelium can be stained for viral '''antigen''' by '''immunofluorescence'''

===Clinical Signs===

*recovering animals may show an immune-mediated uveitis with corneal opacity

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Other organs may also show changes. For example, the wall of the gall bladder may be oedematous, and lymph nodes can be enlarged, reddened and haemorrhagic. Chronic interstitial nephritis may feature.

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====~~Microscopically~~====

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====Histological====

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*basophilic intranuclear inclusion bodies

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Histopathology reveals centrilobular necrosis. Haematoxylin and eosin staining reveals basophilic intranuclear inclusion bodies in hepatocytes and macrophages.

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**in hepatocytes and macrophages

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It is possible to use immunofluorescence to stain for viral antigen in vascular endothelium.

==Treatment==

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