Changes

Infectious Canine Hepatitis (view source)

Revision as of 15:52, 5 July 2010

443 bytes removed , 15:52, 5 July 2010

→‎Pathogenesis

Line 27: Line 27:

===Pathology===

−

~~====Pathogenesis====~~

−

Canine adenovirus 1 (CAV1) initially infects and replicates in the cells of the oropharynx, before establishing a viraemia. A tropism for endothelial cells exists, leading to attack of the liver sinusoids and the lining of the gall bladder. Kuppfer cells are also affected. This results in hepatitis.

−

~~In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.~~

====Gross====

The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Ascites results from this hepatitis, and fibrinous or fibrino-haemorrhagic adhesions can sometimes be seen between the lobes of the liver.

Lizzies

6,502

edits