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Gastric Ulceration - Dog (view source)

Revision as of 14:51, 3 August 2010

391 bytes removed , 14:51, 3 August 2010

→‎Acid-base correction

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*If metabolic alkalosis: replace volume defecit with intravenous NaCl and KCl.

*Blocking of acid secretion:

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[[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|Histamine receptor antagonists]]include

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[[Gastroprotective Drugs#Histamine (H2) Receptor Antagonists|Histamine receptor antagonists]] include

cimetidine, ranitidine and famotidine.

Omeprazole inhibits the hydrogen-potassium ATPase which prevents hydrogen ion production by the parietal cell. This is the drug of choice to treat ulceration associated with mass cell tumours and gastrinomas.

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**Gastrin antagonists:

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***proglumide

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**Acetylcholine receptor antagonists:

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***atropine

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***pirenzepine

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**Adenyl cyclase inhibitors:

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***[[Gastroprotective Drugs#Prostaglandin E Analogues|prostaglangin E2 (PGE) analogues]] (misoprostol)

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**[[Gastroprotective Drugs#Proton Pump Inhibitors|H<sup>+</sup>:K<sup>+</sup>ATPase inhibitors ]]:- for use when patient is refractory to histamine antagonists

***omeprazole - good for exercise induced gastric ulceration

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