Changes

Fasciolosis (view source)

Revision as of 17:53, 5 August 2010

444 bytes removed , 17:53, 5 August 2010

Line 50: Line 50:

===Pathology===

In acute fasciolosis, immature flukes grow and migrate within the liver parenchyma, causing necrotic tracts and haemorrhage. Damage to hepatocytes releases GDH, accounting for the elevation detectable in serum levels. The liver is also subject to post-necrotic scarring, where necrotic areas shrink and fibrose and normal tissues hypertrophy.

−

~~e migrating flukes → liver~~

−

~~necrosis → anaerobic conditions → clostridial multiplication → toxin~~

−

~~production → disease~~

−

The acute disease is a less common type of Fasciola hepatica, and generally occurs 2-6 weeks after large ingestion of metacercariae. The young liver flukes migrate through the liver parenchyma causing severe haemorrhaging, due to the damage to the [[Liver - Anatomy & Physiology|liver]] vasculature.

Lizzies

6,502

edits