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Fasciolosis (view source)

Revision as of 18:08, 5 August 2010

1,133 bytes removed , 18:08, 5 August 2010

→‎Pathology

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**Gamma glutamyl transpeptidase released by damaged cells

**Ulceration and haemorrhage of bile duct → epithelial hyperplasia and increased mucosal permeability

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*'''Anaemia'''

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**250 flukes → up to 50ml of blood loss daily → 10 times increase in rate of erythropoiesis → normochronic anaemia until iron stores are exhausted → hypochromic anaemia.

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*'''Hypoalbuminaemia'''

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**Albumin (and other plasma proteins) lost into bile duct because of

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~~#Whole blood loss~~

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~~#Increased epithelial permeability~~

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** → Increased catabolic rate by 2.5x → increased nitrogen loss via urine

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**The effects seen depend on the magnitude of nitrogen loss

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~~#There is no obvious effect (although animal is still in abnormal physiological state)~~

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~~#Reduced weight-gain and/or wool growth and/or milk production~~

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~~#Loss of body tissue (i.e. weight-loss); hypoalbuminaemia → reduced plasma oncotic pressure → oedema~~

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This is usually seen in late winter, early spring and is currently the most common fascoloiasis seen. It occurs around 4-5 months after ingestion of the metacercariae. Hypochromic and macrocytic anaemia and hypoalbuminaemia are common, as the adult flukes are capable of sucking up to 0.5ml of blood each day. In heavy infections, this can prove to be a severe loss.

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