Changes

==Cytotoxic T-Cells==

==Cytotoxic T-Cells==

 

Cytotoxic T cells kill virus infected cells where the organisms are contained in the cell cytoplasm. Viruses are obligate intracellular pathogens that use the host cell machinery for pathogen protein synthesis; viral peptides associate with MHC class I and are expressed on the cell surface. [[Lymphocytes#Cytotoxic CD8+|CD8+ cytotoxic T-lymphocytes (CTL)]] recognise the antigen-MHC complex.

*Cytotoxic T cells kill virus infected cells (''organisms in cytoplasm'')

* Viruses are intracellular pathogens that use the host cell machinery for pathogen protein synthesis.

** Viral peptides associate with MHC class I and are expressed on the cell surface.

*** [[Lymphocytes#Cytotoxic CD8+|CD8+ cytotoxic T-lymphocytes (CTL)]] recognise the antigen-MHC complex.

* Cytotoxic T-cells secrete a pattern of cytokines similar to that of TH₁ cells.

* Cytotoxic T-cells secrete a pattern of cytokines similar to that of TH₁ cells.

** I.e. IFNγ but not IL-2.

** I.e. IFNγ but not IL-2.