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Coagulation Factor Deficiency (view source)

Revision as of 20:09, 29 September 2010

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==Factor VIII ==

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Factor VIII is known as antihaemophilic factor (AHF); a deficiency of this factor causes 'haemophilia A'. In haemophilic conditions:

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*The primary thrombocyte plug is abnormal with more vascular channels than usual and less fibrin-collagen contact around the edges.

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*Plugs are therefore easily dislodged which results in rebleeding.

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*Secondary plugs only form with difficulty.

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Haemophilia is reported in horses and in around 20 breeds of dogs - it is known to be a sex-linked recessive condition associated with the X chromosome which affects only males.

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* Factor VIII is known as antihaemophilic factor (AHF).

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The severity of the disease correlates with the Factor VIII levels. Haematomas and haemarthrosis are common lesions.

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* Deficiency of this factor causes '''haemophilia A'''.

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** The primary thrombocyte plug is abnormal.

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*** More vascular channels than usual.

−

*** Less fibrin-collagen contact around the edges.

−

** Plugs are therefore easily dislodged.

−

*** Results in rebleeding.

−

*** Secondary plugs only form with difficulty.

−

* Haemophilia is reported in horses and in around 20 breeds of dogs.

−

* Haemophilia is as a sex-linked recessive condition.

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** Associated with the X chromosome.

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** Affects males only.

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* The severity of the disease correlates with the Factor VIII levels.

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* Haematomas and haemarthrosis are common lesions.

==Factor IX ==

Suzannah.stacey

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