Changes

==Pathogenesis==

==Pathogenesis==

*FeLV is the "disease of friends": transmission usually occurs through '''mutual grooming'''

FeLV is the "disease of friends": transmission usually occurs through mutual grooming. From the oropharynx, the virus spreads to most tissues in the body to replicate, notably:

*From the oropharynx, virus spreads to most tissues in the body to replicate, notably:

*Bone marrow

**Bone marrow

*Thymus

**Thymus

*Salivary glands

**Salivary glands

*Reproductive tract

**Reproductive tract

Most kittens but only 30% of adults become '''viremic''' for life without producing antibody. The condition progresses in various forms:

*Most kittens but only 30% of adults become '''viremic''' for life without producing antibody

*20% of viremic cats die of tumors

**20% of viremic cats die of tumors

*30% of viremic cats die of FeLV-associated disease

**30% of viremic cats die of FeLV-associated disease

*80% die within three years of exposure

**80% die within three years of exposure

30% of adults exposed become '''latently infected''' and can become viremic when immunosuppressed.

*30% of adults exposed become '''latently infected''' and can become viremic when immunosuppressed

40% of exposed adults remain healthy and develop Ab and CD8+ T cells after clearing the virus, without becoming reinfected or silent carriers.

*40% of exposed adults remain healthy and develop Ab and CD8+ Tcells after clearing the virus, without becoming reinfected or silent carriers

==Clinical Signs==

==Clinical Signs==