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Feline Leukaemia Virus (view source)

Revision as of 15:40, 30 October 2010

413 bytes added , 15:40, 30 October 2010

→‎Antigenicity

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==Antigenicity==

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*Main envelope protein: gp70

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Viral subgroups have been categorised based on the different abnormalities detected in the host cellular envelope protein gp70. This protein interacts with a cellular receptor, and can prevent already infected cells from being targeted by further viral organisms.

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*3 antigenic subgroups:

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*Group A

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**is transmitted between cats

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**is monotypic: one vaccine covers all isolates

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**causes '''lymphosarcoma'''

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*Group B:

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**is recombinant with ~~transmissible FeLV-A~~

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**increases the chance of '''thymic tumors'''

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*Group C:

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**is a ~~mutant of A~~

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**isolates are rare, and ~~occur as A+C mixtures~~

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**increases chances of '''anemia'''

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There are 3 antigenic subgroups which are defined by the gp70 regulated viral response:

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*Group A is transmitted between cats and is monotypic: one vaccine covers all isolates. Infection with this viral subgroup leads to '''lymphosarcoma'''.

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*Group B is recombinant with transmissible FeLV-A; infection with viruses of this subgroup increases the chance of developing '''thymic tumors'''.

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*Group C is a mutant of subgroup A. Isolates are rare, and occur as A+C mixtures, leading to an increased chance of developing '''anemia'''.

==Diagnosis==

Suzannah.stacey

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