Bones Metabolic - Pathology

Pituitary

• Growth hormone
  • Secreted by the anterior pituitary
  • Influences the size of the skeleton and soft tissue

Thyroid

• Thyroid hormones affect maturation of growth of cartilage

Adrenal glands

• Hyperadrenocorticism

Osteomalacia

• Failure of mineralisation of osteoid / softening of the bones
• Active resorption of bone replaced by excess osteoid on trabeculae, endosteum of cortices and Haversian canals
• Decreased resistance to tension -> osteoid build-up at tendon insertions
• In advanced disease
  • Bones break easily and become deformed
  • Tendons may separate from bones
• Caused by prolonged phosphorus and Vitamin D deficiency
  • Vitamin D maintains normal plasma levels of calcium and phosphorus through acting on the intestines, bones and kidneys
• In mature animals
• Mainly grazing ruminants following gestation and lactation
  • Sunlight is important for production of vitamin D in the skin of ruminants
  • Vitamin d is also present in sun-dried hay
  • Mostly seen where there is long grass growing season with poor sunlight

Hypovitaminosis A

• Vitamin A is essential for normal bone growth in foetus and neonates
• Hypovitaminosis from dietary deficiency of dam -> teratogenic in pigs and large cats
• More commonly, deficiency in neonates (puppies, kittens, calves, piglets) on vitamin-deficient diets
• Dietary deficiency -> failure of osteoclastic remodelling resulting in bone overgrowth and nerve compression
• Optic nerves particularly affected

Hypervitaminosis A

Hypervitaminosis A (Image sourced from Bristol Biomed Image Archive with permission)

• Main lesions:
  • Injury to growth cartilage -> premature closure of growth plate
  • Osteoporosis
  • Exostoses
  • Osteophyte formation in prolonged exposure
• In cats fed bovine liver for prolonged periods
  • Rich in vitamin A in grazing animals
  • Vertebrae fuse with each other due to bone proliferation - cervical spondylosis (ankylosing exostosis of the vertebral column), especially in the neck
• Can also be teratogenic, especially in pigs (cleft plate and abortions)

Hypervitaminosis D

• May be of dietary or iatrogenic origin (has narrow safety margin)
• Key features are hypercalcaemia with metastatic calcification of soft tissues
• Acute poisoning
  • In dogs and cats often from rodenticides containing cholecalciferol
  • Grossly:
    • Gastrointestinal haemorrhage
    • Foci of myocardial discoloration
  • Microscopically:
    • Mucosal haemorrhage
    • Necrosis of crypts
    • Focal myocardial necrosis
    • Mineralisation of intestinal mucosa, blood vessel walls, lungs and kidneys
• Chronic poisoning
  • Grossly:
    • Intense osteoclastic activity -> active resorption of bone, especially trabecular
  • Microscopically:
    • Excessive production of osteoid - appears both eosinophilic and basophilic in different places
    • Marrow cavity may be obliterated
    • Mineralisation of soft tissues, especially blood vessel walls
  • Due to inhibition of Parathyroid Hormone (PTH)|PTH and increase of calcitonin

Fluorine poisoning

• F is widespread in nature
• Pastures may be contaminated by industrial processes (e.g. brick manufacture)
• Acute poisoning:
  • Gastroenteritis
  • Nephrosis
• Chronic poisoning:
  • Dental abnormalities
    • Intoxication during teeth development
    • Foci of poor enamel formation - yellow, dark brown/black, chalky
    • Irregular wear of teeth, chip easily
  • Osteodystrophy = Fluorosis
    • Generalised skeletal disturbance
    • Most affected are metatarsals and mandibles
    • Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities

Lead poisoning

• Lead can bind to mineral portion of bone and cartilage
• In young animals ingesting large dose at once
  • -> Lead induced malfunction of osteoclasts
  • -> Transverse band of increased density on radiographs of metaphysis = "lead line" = growth retardation lattice