Adrenogenital Syndrome

From WikiVet English
Jump to navigation Jump to search
Anatomy and PhysiologyWikiAnt and Phys Banner.png
()Map REPRODUCTIVE SYSTEM (Map)
FERTILISATION , IMPLANTATION AND EARLY EMBRYONIC DEVELOPMENT
SEXUAL DIFFERENTIATION



Aetiology

  • Genotype is XX as should be female
  • Ovaries develop normally
  • Foetal Adrenal Gland is hyperactive and secretes large quantities of Adrenal Androgens, due to a 21 hydroxylase mutation.


Consequence

  • Wolffian Ducts persist due to the presence of Androgens, thus allowing development of male internal and external genitalia.
  • Mullarian Ducts persist due to the absence of testes, hence absence of Sertoli cell MIH secretion. This allows formation of female internal genitalia.


Morphology

  • Appears male with a micropenis and scrotum
  • Both male and female internal genitalia