Glanders

• Caused by Burkholderia (Pseudomonas) mallei
• Exists in eastern Europe and Asia
• Notifiable in UK
• Characterised by multiple small submucosal nasal nodules which liquefy and ulcerate
  • Cores of neutrophils surrounded by a rim of macrophages and granulation tissue
• In addition may have similar nodules in lungs, lymph nodes and cutaneous lymphatics
• Clinical signs: fever and head/ neck lymphadenitis, rhinitis