Equine Serum Hepatitis

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  • reported in horses given serum of equine origin
    • tetanus
    • pregnant mare serum
  • uknown aetiology
    • suggested it may be of infectious cause, perhaps a virus
  • disease manifests itself between one to two months post injection

Clinical

  • jaundice
  • neurological signs
  • death follows quickly

Gross

  • jaundice
  • ascites
  • haemorrhages on and in many organs
  • liver is greeenish with reddish and pale blotches
  • fibrin strands on the liver surface

Microscopically

  • liver cells very fatty (large single vacuoles), some degenerated and a few leukocytes
  • moderate portal fibrosis
  • heavily bile stained
Also known as: Theiller's Disease