Tuberculosis
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Description
A general term for diseases caused by the tuberculous group of bacteria, Mycobacteria species, including Mycobacterium bovis, Mycobacterium tuberculosis,Mycobacterium avium.
Infection can be via inhalation of infective droplets, ingestion of contaminated feed or water, and occasionally via coitus or via milk.
The primary focus of infection is determined by the route of infection. Characteristic granulomatous tubercles develop. These become nectrotic, shedding the infetcive which disseminates to other body systems initiating secondary foci.
- Grossly:
- Yellowish spherical nodules
- Caseous content
- Fibrous capsule usually
- Histologically:
- Granuloma
- Central necrosis
- Epitheliod and giant cells at periphery