Category:Coagulation Defects

Defective Coagulation

• Factor deficiency
  • Often the result of a congenital deficiency in one or more of the coagulation factors.
  • Gives ineffective blood clotting and development of a disease syndrome characterized by excessive bleeding. S
    • Such bleeding is usually detected following trauma or surgery.
      • May occasionally be spontaneous (e.g. into alimentary or urinary tracts).
  • Often seen as familial inherited problems.
    • E.g. haemophilia.
• Vitamin K
  • Absolute or relative deficiency of vitamin K can give rise to abnormal prothrombin levels or activity.
    • Gives defective coagulation.
• Angiostrongylus vasorum
  • Gives defective coagulation in the dog.