Canine X-Linked Severe Combined Immune Deficiency
Revision as of 10:52, 20 August 2010 by Bara (talk | contribs) (Text replace - "Category:To Do - Blood" to "Category:To Do - BloodCategory:To Do - Clinical")
(Canine SCID)
- Affects Basset Hounds and Corgis
- X-linked recessive defect in the gene coding for the IL-2 receptor
- IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
- Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
- Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases