Leptospirosis - Cats and Dogs

Description

Leptospirosis can be caused by infection with a number of different serovars of the bacteria Leptospira interrogans. In general infection with a host adapted strain results in subclinical infection, intermittent shedding of the organism and the animal acts as a reservoir for infection. Infection with non host adapted strains results in clinical disease.

Vaccination against serovars canicola and icterohaemorrhagica has greatly reduced the prevalence and incidence of disease in the UK

• • • Serovars pomona and grippotyphosa are becoming important
    • The host-adapted serovar canicolar causes acute renal failure in puppies; a chronic uraemic syndrome may follow
    • Incidental infections with serovar icterohaemorrhagica or copenhagenii cause renal failure
    • L. icterohaemorrhagiae may cause hepatic jaundice
    • Serovar bratislava causes abortion and infertility in dogs, which may be the maintenance host
    • Infections uncommon in cats

• Leptospirosis icterohaemorrhagica - a septicaemic disease which affects the liver
• puppies
• Leptospirosis is an important spirochaetal group of diseases causing disease in animals and humans (zoonotic)
• Transmission
  • via urine of affected animals
  • organisms can remain viable for weeks in damp conditions
• method of action
  • cause anaemia via intravascular haemolysis

Signalment

Leptospirosis can affect dogs of any age, breed or sex. Young male, adult working dogs are at greatest risk.

Diagnosis

Clinical Signs

• fever
• dehydration
• haemorrhaging from the mucous membranes of the body

Laboratory Tests

• dark field microscopy on fresh urine is best

Pathology

Grossly-

• widespread hameorrhages
• icterus
• pale foci in the liver (not always a constant finding)
• subcapsular and cortical renal haemorrhages

Microscopically-

• foci of necrosis
• dissociation of hepatocytes form each other (similar to post mortem change)
• substantial haemosiderin in the Kuppfer cells (from the haemolysis)
• need to use a silver stain or immunofluorescence to demonstrate the organisms in tissues

References

• Merck & Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial
• Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier