Difference between revisions of "Acute Bovine Pulmonary Emphysema and Oedema"

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[[Category:Respiratory Diseases - Cattle]]
 
[[Category:Respiratory Diseases - Cattle]]
 
[[Category:Pneumonia]]
 
[[Category:Pneumonia]]
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[[Category:To Do - Respiratory]][[Category:To Do - Major]]

Latest revision as of 14:58, 9 May 2011

Acute bovine pulmonary emphysema and oedema (ABPEE)

Fog fever (Image sourced from Bristol Biomed Image Archive with permission)
Fog fever (Image sourced from Bristol Biomed Image Archive with permission)
Tracheal haemorrhages in fog fever (Image sourced from Bristol Biomed Image Archive with permission)
  • Synonym: fog fever
  • Usually seen in adult beef cattle in the autumn as an outbreak
  • Associated with a change in pasture (from dry to lush, green)
  • Severe respiratory distress with laboured breathing and grunting on expiration
  • Causes Interstitial Pneumonia
  • Can result in diffuse fibrosing alveolitis
  • Gross appearance is that of enlarged wet lungs, the interlobular septa are markedly widenedith oedema and emphysema
  • Underlying pathogenesis is ingestion of L-tryptophan in the pasture which is metabolised to 3-methylindole -> bloodstream -> lungs -> metabolised into a compound toxic to Type 1 pneumonocytes and non-ciliated bronchiolar epithelium
  • Their loss allows massive flooding of the alveoli with a protein-rich fluid
  • The sequence of events in the lung is as follows:
    • Alveolar flooding with a protein-rich fluid due to the necrosis of Type 1 epithelium
    • As the incoming air dries this fluid, fibrinous 'hyaline membranes' form
    • Proliferation of the more resistant cuboidal Type 2 epithelium which line the alveoli, called 'epithelialisation'
    • Then either there is
      • Digestion of the hyaline membranes by macrophages which when completed, allows some of the proliferated Type 2 epithelium to differentiate into Type 1 and reconstitute the functional respiratory unit - a normal alveolus
    • Or
      • Organisation of the fibrin into fibrous tissue in the lumen - destroying the alveolus or proliferation of fibrous tissue in the alveolar wall with retention of the epithelialised appearance to the alveolus
  • Sequel
    • Residual scarring if animal survives initial onslaught
    • In chronic exposures there may be extensive fibroplasia
  • Ingestion of sweet potatoes ifested with Fusarium solani mould or pasture contaminated with stinkweed or purple mint, rapeseed and kale also cause pulmonary oedema, emphysema and interstitial pneumonia