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==Description==
==Description==
Apergillosis is a disease of the respiratory system caused by several ''[[Aspergillus spp.]]''. ''Aspergillus fumigatus'' is the most frequently reported species in domestic animals but ''[[Aspergillus tereus]]'' has also been implicated. ''Aspergillus'' is a ubiquitous saprophyte and is found worldwide. It is also a component of normal hair, skin and mucosal flora in both humans and animals. Commonly affected species include birds, dogs, cats, horses and cattle but the disease has been reported in many other wild and domestic species.
Apergillosis is a disease of the respiratory system caused by several ''[[Aspergillus spp.]]''. ''Aspergillus fumigatus'' is the most frequently encountered species in domestic animals but ''Aspergillus tereus'' has also been reported. ''Aspergillus'' is a ubiquitous saprophyte and is found worldwide. It is also a component of normal hair, skin and mucosal flora in both humans and animals. Commonly affected species include birds, dogs, cats, horses and cattle but the disease has been reported in many other wild and domestic species.
==Pathogenesis==
==Pathogenesis==
In dogs, spores are inhaled from the environment leading to fungal colonisation of the nasal cavities. Following their deposition in tissue and recognition by phagocytes an inflammatory response is triggered. Haemolytic and dermonecrotic toxins as well as fungal protease and elastase are released leading to tissue damage.
In horses, the pathogenesis of guttural pouch mycosis is largely unknown but is thought to relate to damage to the mucosal layer of the pouches by by trauma or infection. This enables opportunistic Aspergillus fungi to invade into the damaged tissue.
==Clinical signs and features==
==Clinical signs and features==