Difference between revisions of "Burkholderia pseudomallei"
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| − | ''Burkholderia pseudomallei'' is a species of the ''[[Burkholderia species - Overview|Burkholderia]]'' genus. ''B.pseudomallei'' causes [[ | + | ''Burkholderia pseudomallei'' is a species of the ''[[Burkholderia species - Overview|Burkholderia]]'' genus. ''B.pseudomallei'' causes [[Melioidosis]], which is endemic in Asia and Australia. It primarily infects rodents. |
*Pathogenesis: | *Pathogenesis: | ||
**Infection via ingestion, inhalation or skin wounds from environment | **Infection via ingestion, inhalation or skin wounds from environment | ||
Revision as of 09:45, 26 July 2010
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This article is still under construction. |
Burkholderia pseudomallei is a species of the Burkholderia genus. B.pseudomallei causes Melioidosis, which is endemic in Asia and Australia. It primarily infects rodents.
- Pathogenesis:
- Infection via ingestion, inhalation or skin wounds from environment
- Exotoxin, dermonecrotic protease and lecithinase implicated in pathogenicity
- Strain virulence and host immunosuppression important
- Clinical infections:
- Opportunistic infection with stress and immunosuppression predisposing to disease
- Abscesses develop in many organs including lungs, spleen, liver, joints, CNS, upper respiratory tract
- Chronic, debilitating, progressive disease with long incubation period
- Many animal species susceptible
- Referred to as pseudoglanders in horses
- Diagnosis:
- Specimens: pus from abscesses, affected tissues, blood
- Fluorescent antibody technique on tissue smears
- Blood agar and MacConkey agar plates, incubated aerobically
- Colonies have musty smell
- Lactose fermentation on MacConkey
- Slide agglutination
- ELISA, complement fixation and indirect haemagglutination tests for serum antibodies
- Treatment/control: slaughter of infected animals where exotic