Difference between revisions of "CNS Inflammation - Pathology"

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===[[Granulomatous Meningoencephalitis]]===
 
===[[Granulomatous Meningoencephalitis]]===
(GME)
 
* An [[CNS Idiopathic Conditions - Pathology|idiopathic CNS conditon]]
 
* May occur as:
 
** A disseminated disease
 
** A focal mass lesion
 
** A primary occular disease
 
* Brainstem signs are common, although the forebrain is primarily affected.
 
* May be incorrectly diagnosed as lymphoma.
 
* Changes are apparent in the CSF.
 
** There is usually a mononucloear pleocytosis.
 
** Sometimes only protein is elveated.
 
* Diffuse inflammatory changes or a mass lesion will be seen by advanced imaging.
 
** However, biopsy is required for a definative diagnosis.
 
* Life span is between 6 months and 1 year from diagnosis.
 
  
====Treatment====
+
[[Necrotising Meningoencephalitis]]
  
* Immunosuppression:
 
** Corticosteroids
 
** Azathioprine
 
** Cycophosphamide
 
* Surgery
 
** This is only appropriate if there is a focal mass.
 
* Radiation therapy.
 
 
[[Necrotising Meningoencephalitis]]
 
  
[[:Category:CNS Non-Infectious Inflammatory Diseases]]
 
  
  

Revision as of 12:53, 8 March 2011

Central Nervous System Inflammation Overview


Central Nervous System Infectious Inflammation



Category:CNS Non-Infectious Inflammatory Diseases

Granulomatous Meningoencephalitis

Necrotising Meningoencephalitis



Pug Encephalitis

  • A CNS idiopathic condition
  • Affects pugs.
    • Similar conditions are seen in yorkshire and maltese terriers.
  • Officially known as necrotising meningoencephalitis of small dogs.
  • Characterised by histological forebrain inflammation and necrosis.
  • The disease is uniformly fatal.
    • Corticosterid treatment has no effect.


[:Category:CNS Non-Infectious Inflammatory Diseases]]