Difference between revisions of "Canine X-Linked Severe Combined Immune Deficiency"

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*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
 
*Animal usually dies from pneumonia or sepsis as the level of maternal [[Immunoglobulins|antibody]] decreases
[[Category:Primary Adaptive Immunity Deficiencies]][[Category:Immune Diseases - Dog]]
+
[[Category:Primary Adaptive Immunity Deficiencies]][[Category:Immunological Diseases - Dog]]
 
[[Category:To Do - Blood]][[Category:To Do - Clinical]]
 
[[Category:To Do - Blood]][[Category:To Do - Clinical]]

Latest revision as of 16:57, 16 December 2010

(Canine SCID)

  • Affects Basset Hounds and Corgis
  • X-linked recessive defect in the gene coding for the IL-2 receptor
    • IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
  • Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
  • Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases