Canine X-Linked Severe Combined Immune Deficiency
Revision as of 16:57, 16 December 2010 by Bara (talk | contribs) (Text replace - "Category:Immune Diseases - Dog" to "Category:Immunological Diseases - Dog")
(Canine SCID)
- Affects Basset Hounds and Corgis
- X-linked recessive defect in the gene coding for the IL-2 receptor
- IL-2 receptor is a receptor for the cytokine IL-2 which causes T cells to proliferate
- Causes lymphoid hypoplasia, stunted growth and increases the animal's susceptibility to infection
- Animal usually dies from pneumonia or sepsis as the level of maternal antibody decreases