Difference between revisions of "Category:Histotoxic Clostridia"

Revision as of 10:55, 12 May 2010

Exotoxins cause local tissue necrosis and systemic effects which can be fatal - toxaemia
C. chauvei and C. septicum present in muscle as latent spores which can germinate to cause infection
C. novyi type B and C. haemolyticum have latent spores in the liver
When inoculated into wounds, cause malignant oedema and gas gangrene
Endospores persist in the soil
Most ingested spores excreted in faeces, but some become dormant in tissues
Tissue injury leads to reduced oxygen tensions allowing germination and replication of bacteria
Exotoxins cause local necrosis
Activated spores in the liver and muscles cause endogenous infections including blackleg, infectious necrotic hepatitis and bacillary haemoglobinuria
Inoculation of wounds causes exogenous infections including malignant oedema and gas gangrene

Gas gangrene and myositis
- Extensive bacterial invasion of damaged muscle
- Gas production causing subcutaneous crepitus
- Similar manifestations as malignant oedema

Early penicillin
Vaccination with bacterin or toxoid at 3 months and booster after 3 weeks, then annually

The following 6 pages are in this category, out of 6 total.

@@ Line 19: / Line 19: @@
-===Clostridium novyi===
+===[[Clostridium novyi]]===
-*Infectious necrotic hepatitis/black disease:
-**Acute disease of sheep, occasionally cattle
-**Hepatic necrosis caused by exotoxins of ''C. novyi'' type B in liver damaged by ''Fasciola hepatica''
-**Rapid death
-**Dark discoloration of skin caused by subcutaneous venous congestion
-**Fluorescent antibody test diagnostic
-* Causes [[Necrosis - Pathology#Gas Gangrene|gas gangrene]] and [[Muscles Inflammatory - Pathology#Gas gangrene|myositis]].
-*May be involved in [[Bacterial skin infections - Pathology#Systemic bacterial infections|cutaneous lesions]]
-*Causes big head in rams - oedema of subcutaneous tissues of the head, neck and cranial thorax; necrotising lethal alpha toxin