Category:Histotoxic Clostridia
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- Exotoxins cause local tissue necrosis and systemic effects which can be fatal - toxaemia
- C. chauvei and C. septicum present in muscle as latent spores which can germinate to cause infection
- C. novyi type B and C. haemolyticum have latent spores in the liver
- When inoculated into wounds, cause malignant oedema and gas gangrene
- Endospores persist in the soil
- Most ingested spores excreted in faeces, but some become dormant in tissues
- Tissue injury leads to reduced oxygen tensions allowing germination and replication of bacteria
- Exotoxins cause local necrosis
- Activated spores in the liver and muscles cause endogenous infections including blackleg, infectious necrotic hepatitis and bacillary haemoglobinuria
- Inoculation of wounds causes exogenous infections including malignant oedema and gas gangrene
Clostridium chauvei
Clostridium septicum
Clostridium novyi
Clostridium perfringens type A
Clostridium haemolyticum
Clostridium sordelli
- Causes gas gangrene, myositis and abomasitis (lambs)
Treatment of histotoxic infections
- Early penicillin
- Vaccination with bacterin or toxoid at 3 months and booster after 3 weeks, then annually
Pages in category "Histotoxic Clostridia"
The following 6 pages are in this category, out of 6 total.