Category:Liver - Inflammatory Pathology

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Liver - Inflammatory Pathology

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Hepatitis - Term used when the parenchymal lesions in the liver are presumed to be cuased by an infectious agent, inflammation of the liver, response to liver cell necrosis, Kuppfer cells increase in size and number occurs in many cases of hepatitis.


Peliosis Hepatica

Lobular dissecting hepatitis

  • Rare cause of chronic liver failure in young dogs
  • Less than 5yrs of age
  • Standard poodle overrepresented
  • Gross findings:
    • Micronodular microhepatica, ascites, numerous portosystemic shunts
  • Histology:
    • Hepatic architecture disrupted by collagen and reticulin fibres separating the hepatic lobules into small clusters and individual cells
    • Hepatocytes mutlifocally swollen, lightly eosinophilic, some binucleated.
    • Variable nodular regeneration.
    • Scattered necrotic cells and occasional foci of inflammation.
  • Cu2+ accumulation not a consistent finding.
  • Aetiology – possibly a specific reaction pattern in neonatal/juvenile liver .
  • Differentials:
    • Copper toxicity
    • Copper storage disease
    • Aflatoxin
    • Infectious diseases such as Leptospria spp. and CAV-1.

Hepatitis in cats

  • 2 main types
    • cholangiohepatitis
      • cholangitis
      • periportal hepatocellular necrosis
      • neutrophils in the portal areas
      • acute or chronic.
      • Usually male, pure bred
      • Cats more ill than lymphocytic portal hepatitis.
      • Higher ALT and serum bilirubin levels.
    • Lymphocytic portal hepatitis
      • infiltration of portal areas with lymphocytes and plasma cells
      • no cholangitis
      • no periportal hepatocellular necrosis.

Subcategories

This category has the following 3 subcategories, out of 3 total.

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